Premium
P1‐207: Alzheimer's lesions in the brains of young subjects
Author(s) -
Pletnikova Olga,
Rudow Gay L.,
Hyde Thomas M.,
Kleinman Joel,
Ali Sabeen Z.,
Bharadwaj Rahul,
Crain Barbara J.,
Fowler David,
Rubio Ana I.,
Troncoso Juan C.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.407
Subject(s) - asymptomatic , entorhinal cortex , apolipoprotein e , dementia , hippocampus , pathology , alzheimer's disease , neocortex , disease , medicine , cortex (anatomy) , stage (stratigraphy) , neuroscience , psychology , biology , paleontology
Neuropsychiatric Inventory Questionnaire (NPI-Q). Chi-square and t-tests were used for unadjusted analyses and general linear models were used for adjusted analyses. Results: Age at onset and age at death were lower among AD participants with concomitant LBs than those without LB pathology. Men more often had LB pathology. Participants with LBs more often had at least one APOE ε4 allele. After adjustment for age, gender, education, neuritic and diffuse plaque frequency, and tangle stage, scores on the NPI-Q and the mUPDRS were more impaired for participants who had comorbid LB pathology. After additional adjustment of APOE ε4 status, only the mUPDRS showed significantly higher scores among persons who had both AD and LB pathology compared to the group that had AD without LBs. Conclusions: Participants with both AD and LB pathology have a clinical phenotype which may be distinguished from AD alone. The identification of comorbidity in the absence of reliable biomarkers of alpha-synuclein pathology may eventually help in the selection of patients for specific drug therapy.