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P1‐196: Patients with Alzheimer disease respond differently to familiar and unfamiliar music: An fMRI study
Author(s) -
Yang Lillian M.J.,
Shahinfard Elham,
Slack Penelope,
Jacova Claudia,
Kirkland Kevin,
Boyd Lara,
Robin Hsiung Ging-Yuek
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.395
Subject(s) - superior temporal gyrus , audiology , psychology , voxel , insula , stimulus (psychology) , auditory cortex , middle frontal gyrus , functional magnetic resonance imaging , neuroscience , cognitive psychology , medicine , radiology
(p1⁄40.003 for sumscore ofWMHbyone-wayANOVAwithLSDmultiple comparison). The WMH showed a significant correlation with age (r1⁄4 0.453, p<0.001), UPDRS total (r1⁄40.259, p1⁄40.017), MMSE (r1⁄40.558, p1⁄40.000), SOB of CDR (r1⁄40.580, p<0.001), andmanyof the cognitive domains. Themultivariate linear regression model revealed that the WMH was independently associated with cognitive impairment in patientswithDLBandDLB-MCI, regardless of age, gender, education status, andvascular risk factors (p1⁄40.037 for MMSE, p1⁄40.023 for CDR and p1⁄40.035 for SOB of CDR). Conclusions: Our results demonstrated that WMH in DLB group seems more intense than that in DLB-MCI group. These findings reflect that WMH might be associated with cognitive decline in patients with DLB, regardless of age, gender, education status and vascular risk factors. Also this study suggests that other nonvascular factors contribute to the progression of cognitive decline in patients with DLB. The special attentions should be paid on WMH in DLB although the exact pahtophysiologic mechanisms are unclear.