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P1‐185: Prevalence and clinical characteristics of mixed dementia in elderly mexicans
Author(s) -
Mimenza Alberto Jose,
Moreno Cesar,
Aguilar Sara Gloria,
Avila Jose Alberto,
Alvarado Pedro
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.384
Subject(s) - leukoaraiosis , medicine , dementia , diabetes mellitus , family history , dyslipidemia , depression (economics) , vascular dementia , stroke (engine) , univariate analysis , disease , multivariate analysis , pediatrics , endocrinology , mechanical engineering , engineering , economics , macroeconomics
our study was to investigate this effect with respect to cerebral changes by using 18F-fluoro-deoxy-glucose positron emission tomography (FDG-PET). Methods: 29 patients with MCI and mild AD were shown positive and neutral pictures in a free recall-task. According to the respective results, the group was dichotomized into subgroups with a pronounced (mean age: 71.8; SD: 5.9; 11 women, 4 men) vs. a blurred (mean age: 73.5; SD: 4.6; 6 women, 8 men) positivity effect. To investigate the cerebral correlates of the positivity effect, FDG-PET scans obtained in the subgroups were compared by using SPM 8 with severity of cognitive impairment (MMSE scores) as a covariate. Results:Patients with positivity effect show a significantly higher glucose uptake in the right occipital gyrus and the left cuneus; the right medial and the left superior frontal gyrus as well as in the right parahippocampal gyrus and left insula compared with patients without positivity effect. Conclusions: The results of our ongoing study confirm the positivity effect in patients with MCI and mild AD and demonstrate that this effect involves the cuneus, limbic and frontal regions. These findings lead to the hypothesis that the positivity effect involves a compensatory role of an emotion network in memory performance.