Premium
P1‐184: Positivity effect in memory performance: Cerebral correlates in MCI and mild Alzheimer's disease—an FDG‐PET study
Author(s) -
Gorenc-Mahmutaj Lina Sidonija,
Kowoll Magdalena Eva,
Urbanowitsch Nadja,
Wetzel Petra,
Meyer-Kuehling Inga,
Wendelstein Britta,
Giesel Frederick,
Haberkorn Uwe,
Funke Joachim,
Schröder Johannes
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.383
Subject(s) - cuneus , parahippocampal gyrus , lingual gyrus , medicine , audiology , positron emission tomography , alzheimer's disease , insula , psychology , cardiology , cognition , disease , neuroscience , radiology , temporal lobe , precuneus , epilepsy
(CN). All underwent structural and rs-fMR imaging at 3T. Presence of LI in basal ganglia, thalami, capsulae and deep white matter was ascertained using fluid attenuation inversion recovery images and University of Edinburgh Neuroimaging Stroke Scale by two independent raters blinded to diagnoses. In total, 22 MCI patients with LI (MCI-LI), 26 MCI patients without LI (MCI-no LI) and 28 CN without LI were included. Functional volumes were post-processed using regional homogeneity (ReHo) and the amplitude of low-frequency fluctuation (ALFF) methods. Differences in ALFF and ReHo values were assessed using analysis of covariance. Between group voxel-wise comparisons using t-test were conducted, controlling for age, sex, years of education and modulated grey matter maps obtained from T1 segmentation. Differences were considered significant when p<0.05, AlphaSim corrected. ALFF and ReHo were correlated with global cognitive scores. Results: Compared with CN, the MCI-LI patients had lower ReHo and ALFF in precuneus/ cuneus (PCC), insula and medial frontal gyrus (MFG). Compared to MCI-no LI, MCI-LI patients had lower ALFF in superior-medial frontal gyrus (SFG), MFG, anterior cingulate cortex (ACC) and lower ReHo in PCC and insula. Conversely, MCI-no LI patients had greater ReHo andALFF in the hippocampi and parahippocampal gyri, SFG, MFG, ACC, and greater ALFF in left caudate. Montreal Cognitive Assessment score correlated with ALFF in MFG (r1⁄40.43, p1⁄40.045) in MCI-LI patients. Conclusions:MCI-LI patients are char-