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P1‐176: Distinctive resting state network disruptions among Alzheimer's disease, subcortical vascular dementia, and mixed dementia patients
Author(s) -
Kim Hee Jin,
Cha Jungho,
Lee Jong Min,
Shin Ji Soo,
Jung Na Yeon,
Kim Yeo Jin,
Cheo Yearn Seong,
Lee Kyung Han,
Kim Sung Tae,
Kim Jae Seoung,
Lee Jae-Hong,
Na Duk L.,
Seo Sang Won
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.375
Subject(s) - dementia , default mode network , posterior cingulate , resting state fmri , vascular dementia , superior frontal gyrus , neuroscience , medial frontal gyrus , inferior parietal lobule , psychology , cardiology , medicine , functional connectivity , disease , cortex (anatomy) , functional magnetic resonance imaging
patients and care plan altered in 22 patients). A positive PET scan resulted in change of management plans (either medication, care, or both) nine times more often than a negative PET scan (n1⁄461 vs. n1⁄47; p<0.001). For 43 (22%) patients, additional ancillary investigations were planned after PET results were disclosed, predominantly when PET results were negative (n1⁄433; p<0.001). In patients with a pre-PET AD diagnosis and a positive PET scan, additional ancillary investigations were less often requested compared to patients with a negative PET scan (p<0.001). Conclusions: [F]Flutemetamol PET increased physician’s overall confidence in clinical diagnosis. In addition, it altered diagnostic work-up and healthcare management plan of young onset dementia patients visiting a tertiary memory clinic.