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P1‐175: Diffusion tensor metrics as biomarkers in idiopathic normal‐pressure hydrocephalus
Author(s) -
Kang Kyunghun,
Choi Dongho,
Ko Pan-Woo,
Lee Ho-Won,
Yoon Uicheul
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.374
Subject(s) - diffusion mri , white matter , fractional anisotropy , ventriculomegaly , medicine , corticospinal tract , cardiology , cingulum (brain) , magnetic resonance imaging , corpus callosum , normal pressure hydrocephalus , optic radiation , neuroscience , pathology , audiology , psychology , radiology , dementia , disease , pregnancy , fetus , genetics , biology
patients and care plan altered in 22 patients). A positive PET scan resulted in change of management plans (either medication, care, or both) nine times more often than a negative PET scan (n1⁄461 vs. n1⁄47; p<0.001). For 43 (22%) patients, additional ancillary investigations were planned after PET results were disclosed, predominantly when PET results were negative (n1⁄433; p<0.001). In patients with a pre-PET AD diagnosis and a positive PET scan, additional ancillary investigations were less often requested compared to patients with a negative PET scan (p<0.001). Conclusions: [F]Flutemetamol PET increased physician’s overall confidence in clinical diagnosis. In addition, it altered diagnostic work-up and healthcare management plan of young onset dementia patients visiting a tertiary memory clinic.