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P1‐170: Anterior cingulate and insular glucose hypometabolism associated with depressive symptoms in older adults with subjective cognitive impairment (SCI)
Author(s) -
Oonuma Jiro,
Odano Ikuo,
Ito Masatoshi,
Meguro Kenichi
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.369
Subject(s) - anterior cingulate cortex , dementia , statistical parametric mapping , insula , posterior cingulate , psychology , population , neuroimaging , cognition , medicine , audiology , psychiatry , neuroscience , magnetic resonance imaging , disease , environmental health , radiology
Using DTI-MRI, to assess the involvement of the Corpus Callosum (CC), the cingulum, and other nerve pathways, both in healthy individuals and in patients with Alzheimer’s Disease Dementia (ADD). Methods:Thirty-three patients were included in the study: 16 healthy controls [age: (mean6Standard Deviation) 73.3166.48 years; education: 12.0664.15 years, MMSE: 29.5660.62], and 17 patients with probable ADD (NINCDS-ADRDA) [age: 75.0668.84 years; education: 11.6564.47 years, MMSE: 20.6566.42], right-handed, paired by age, education, and Beck’s inventory. A full neuropsychological test battery was administered, and DTI-MRI was taken (21 directions, 3-mm slice thickness). FA and MD findings were analyzed at the level of the CC, the cingulum, and of other selected pathways. Demographic data and findings of DTI-MRI were analyzed by ANOVA among the groups. Results:Regarding FA, patients with ADD presented with lower values than healthy controls at the left cingulum (cingulate-gyrus area1⁄4p:0.001; hippocampus area1⁄4p:0.001), and the right cingulum (cingulate-gyrus area1⁄4p:0.023), and at the left CC (genu1⁄4p:0.003; corpus1⁄4p:0.022; splenium1⁄4p:0.005), and the right CC (genu1⁄4p:0.005; corpus1⁄4p:0.011; splenium1⁄4p:0.002). In terms of MD, patients with ADD presented with the highest values at the left cingulum (cingulate-gyrus area1⁄4p:0.001; hippocampus area1⁄4p<0.001), and the right cingulum (cingulate-gyrus area1⁄4p<0.001; hippocampus area1⁄4p:0.004), and at the left CC (genu1⁄4p:0.006; corpus1⁄4p:0.016; splenium1⁄4p:0.006), and the right CC (genu1⁄4p:0.019; corpus1⁄4p:0.018; splenium1⁄4p:0.001). Conclusions:The involvement of the WM microstructure in patients with ADD was evidenced through FA and MD measurements, at highly relevant pathways for cognitive performance.