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P1‐156: Targeting amyloid peptide using metal complexes
Author(s) -
Domingo Porqueras Diego Santo,
Tripier Raphaël,
Beyler Maryline,
Salerno Milena
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.355
Subject(s) - intracellular , extracellular , chemistry , cyclen , dota , cyclam , hepes , peptide , biophysics , stereochemistry , metal , biochemistry , chelation , biology , inorganic chemistry , organic chemistry
International audienceWe studied the cellular transport of copper complexes based on cyclam or cyclen macrocycles as copper 64 can be used as radiotracer for Positron Emission Tomography (PET). We also studied the transport of europium complexes of “dota like” macrocycles, as analogues for the widely used Gd3+ chelate-based Magnetic Resonance Imaging contrast agents (MRI CAs). The ligands used here, could be used as scaffolds where molecules able to recognize Aβ peptide could be conjugated (e.g. azure c, ANS or Benzofuran derivatives…)