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P1‐153: The 2D‐MTA is a feasible method for assessing atrophy of the medial temporal lobe in daily clinical practice
Author(s) -
Menendez-Gonzalez Manuel,
Álvarez-Avellon Tania,
Oliveira Anibal Fernandez,
Bayón Francisco Conejo,
Maese Jesús,
Uzal Tamara Mesas,
Martínez-Camblor Pablo
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.352
Subject(s) - atrophy , coronal plane , medicine , temporal lobe , magnetic resonance imaging , nuclear medicine , psychology , radiology , pathology , neuroscience , epilepsy
interpretation changes after quantitative information was considered and whether or not this information improved the inter-rater agreement of interpretations. We also examined how the Visual Reads and VisualQuant Reads compare to a purely quantitative read where a scan was determined to be elevated based on an SUVR>1.1 in six regions of interest (anterior cingulate, inferior medial frontal, lateral temporal, posterior cingulate, precuneus, and superior parietal). Simple percent agreement and Cohen’s kappa were used to measure agreement. Results:60 scans were interpreted by two blinded raters. The initial Visual Read was changed after the introduction of quantitative information in 6.7% (n1⁄44) of scans for Rater 1 and 11.7% (n1⁄47) for Rater 2. Initial Visual Reads were changed from non-elevated to elevated in 9 of the 11 (81.8%) scans that were changed. Agreement of reads across raters was 90% (54 of 60; Kappa1⁄40.75) for Visual Reads and increased to 95% (n1⁄457, Kappa1⁄40.89) for the VisualQuant Reads. Quantitative only assessments (SUVR >1.1) were concordant with VisualReads (86.7% for Rater 2 and 90.0% for Rater 1) but concordance was higher with the VisualQuant Reads (95.0% 96.7%). Conclusions:Augmenting the radiological interpretation of amyloid PET scans with quantitative information appears to improve the consistency in interpretations for the early detection of the presence of cerebral amyloid accumulation.