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P1‐149: Structural MRI and amyloid PET imaging for prediction of conversion to Alzheimer's disease in patients with mild cognitive impairment: A meta‐analysis
Author(s) -
Park Woon Yeong,
Kim Sang Hoon,
Park Sang Hag,
Kim Seung Gon,
Park Shin Young,
Seo Eun Hyun,
Choo Il Han
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.347
Subject(s) - biomarker , positron emission tomography , magnetic resonance imaging , medicine , neuroimaging , neurodegeneration , oncology , amyloid (mycology) , meta analysis , disease , nuclear medicine , radiology , pathology , psychiatry , biochemistry , chemistry
each population separately. Results: Figure 1 shows 12 transverse slices of the average WMH maps for the entire PREVENT-AD and ADC populations overlapped on the ADNI template. Conclusions:WMHs have been observed in normal control subjects at risk of AD as well as NC/MCI/AD population. WMHs occur more often in the periventricular areas especially adjacent to the horns of the lateral ventricles and less often in the other areas. The difference between the two maps suggests that WMHs are more extensive in AD populations than in healthy controls at risk of AD, especially in regions such as parietal lobe suggesting the probability of an inhomogeneous spread of the WMHs in different regions. (Funding: CIHR MOP-111169, P30 AG010129, Pfizer Canada, FRQ-S, and Douglas Hospital Research Centre.)