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P1‐143: Early detection of amnestic mild cognitive impairment from normal cognition or dementia by neurometabolites of the brain with magnetic resonance spectroscopy in a chinese population
Author(s) -
Zhang Liping,
Shi Jing,
Tian Jinzhou,
Zhang Xuekai,
Wei Mingqing,
Ni Jingnian,
Li Ting,
Wang Yongyan
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.341
Subject(s) - dementia , posterior cingulate , creatine , medicine , voxel , nuclear medicine , magnetic resonance imaging , population , temporal lobe , pathology , audiology , cognition , radiology , psychiatry , epilepsy , disease , environmental health
large group of cognitively normal (CN), individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Methods: 324 CN, 502 individuals with MCI, and 182 with AD were selected from the Alzheimer’s Disease Neuroimaging Initiative database. We included participants only if [18F] florbetapir positron emission tomography (PET), conducted within 3 month of a clinical and cognitive assessment visits, and APOE genotype information is available. To determine main effects and interactions of APOE ε4 and Ab burden on the scores, a series of 2 X 2 analysis of covariance, with age, gender, and education as covariates, was performed. Results: The influence of APOE ε4 status and Ab positivity on cognitive function, clinical severity, and functional status were minimal in CN and AD. In MCI, main effect of APOE ε4 was dominantly observed in executive function, with ε4 carriers exhibiting poorer performances. Ab positivity had no influence over this association. Main effect of Ab positivity was significant in global cognition, memory, and visuospatial ability, with MCI individuals of high Ab burden exhibiting poorer performances. However no single measure of the executive function domain was influenced by Ab positivity (Figure). Interactive effects of Ab positivity and APOE ε4 status were found in the measures of global cognition, verbal recognition memory, and clinical severity. Conclusions:We provided further evidence that APOE ε4 and Ab plays independent and interactive roles in cognitive functions from the large sample of CN, MCI, and AD. In MCI, the influences of APOE ε4and Ab burden status on executive and non-executive functions were found in a manner of dissociable pattern.