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P1‐129: Effect on white matter hyperintensity on depressive symptoms according to the presence of the apolipoprotein e (ApoE) ε4 allele in the elderly: A credos (clinical research center for dementia of South Korea) study
Author(s) -
Chang Ki Jung,
Son Sang Joon,
Hong Chang Hyung,
Lee Kang Soo,
Roh Hyung Woong
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.327
Subject(s) - geriatric depression scale , apolipoprotein e , dementia , mood , psychology , depression (economics) , medicine , center for epidemiologic studies depression scale , clinical dementia rating , clinical psychology , psychiatry , depressive symptoms , cognition , disease , economics , macroeconomics
wake cycle, as well as subjective sleep quality were obtained. These variables were correlated to florbetapir-PET data, FDG-PET and structural T1 MRI, using a voxel-wise approach in SPM5. Results were considered as significant at p<0.001 with a cluster size adjusted for a corrected p< 0.05 determined byMonte-Carlo simulation.Results: Longer sleep latencywas associated with greater Ab burden in prefrontal areas. This correlation remained significant after adjustment for age, ApoE4 status, anxiety and depression scores (Figure 1). In contrast, there was no significant correlation between sleep variables and grey matter volume or metabolism. Conclusions: In healthy asymptomatic participants, difficulties falling asleep estimated by longer sleep latency are associated with greater Ab burden in brain areas known to be early affected by amyloid deposition. The direction of the relation remains however to be established. This finding extends previous studies showing that lifestyle factors such as cognitive activity or physical exercise may also reduce the risk of cognitive decline and forestall ADrelated pathology. Although requiring confirmation with objective measures of sleep, our data highlight the importance of preserving sleep quality in older adults, and even more in individuals at risk for AD.