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P1‐104: CSF tau predicts working memory and global cognitive decline in autosomal dominant Alzheimer's disease
Author(s) -
Hassenstab Jason,
Lim Yen-Ying,
Fagan Anne M.,
Ma Shengmei,
Xiong Chengjie,
Buckles Virginia,
Bateman Randall,
Morris John C.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.302
Subject(s) - clinical dementia rating , cognitive decline , cognition , dementia , episodic memory , asymptomatic , psychology , neuropsychology , alzheimer's disease , medicine , working memory , effects of sleep deprivation on cognitive performance , psychiatry , disease
all follow-up evaluation, and there was no significant difference between the subjects who remained and dropped out in terms of education, occupation, and apo e4 status. Logical regression was utilized to identify risk of dementia. Results:We found that baseline LCP was associated with four-fold increased risk of dementia despite the fact that individuals with LCP did not decline in cognitive performance during the initial four years. We also identified illiteracy as the most significant risk factor predicting all types of dementia followed by fewer years of education and occupation involving manual labor. Apo e4 was only significant a risk for the dementia of the Alzheimer’s type. Conclusions: LCP associated with low education was found to be a significant risk for dementia. Among the demographic factors literacy was found to be the most significant protector against dementia.