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P1‐100: A cross‐sectional and longitudinal investigation of the cambridge behavioral inventory‐revised (CBI‐R) in behavioral variant frontotemporal dementia
Author(s) -
Gordon Elizabeth,
Warren Jason D.,
Fox Nick C.,
Rohrer Jonathan D.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.297
Subject(s) - psychology , mood , frontotemporal dementia , dementia , longitudinal study , clinical psychology , audiology , disease , medicine , pathology
in cases with MCI and AD compared to healthy elderly cases. Lower CSF levels of Ab38 and Ab40 were consistently associated with increased WMH load in all subgroups, including healthy elderly, cases with SCD and cases with MCI. These significant associations were found in both APOE4-positive and APOE4-negative cases. When studying the regional distribution of WMH we found that CSF Ab38 and Ab40 were associated with WMH load in frontal, temporal and parieto-occipital regions, but not in infratentorial regions. Low levels of CSF Ab42 and high levels of [18F]flutametamol uptake (reflecting Ab fibrils) were less consistently associated with WML load and mainly with WMH in the temporal lobe. Neither CSF Ab species nor [18F]flutametamol uptake were associated with the presence of lacunes. Conclusions: In this large and prospective study we found that CSF Ab38 and Ab40, and to lesser degree Ab42, are consistently associated with WMH independent of cognitive status. We hypothesize that deposition of Ab38 and Ab40 in the vasculature might cause changes of the vessel walls, increasing the risk of ischemia of the white matter.