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P1‐095: Odor identification in frontotemporal dementia, Alzheimer's disease, and major depression
Author(s) -
Kansal Kalyani,
Kamath Vidyulata,
Mechanic-Hamilton Dawn,
Irwin David J.,
Moberg Paul J.,
Turetsky Bruce I.,
Grossman Murray,
Arnold Steven E.,
Onyike Chiadi U.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.292
Subject(s) - frontotemporal dementia , psychology , orbitofrontal cortex , audiology , dementia , major depressive disorder , depression (economics) , olfaction , alzheimer's disease , cohort , psychiatry , disease , neuroscience , clinical psychology , medicine , cognition , prefrontal cortex , economics , macroeconomics
Background:MicroRNAs are implicated in the pathogenesis of Alzheimer’s disease (AD). However, the change of microRNA expression and the impact of dys-regulated microRNAs in AD remains unclear. Methods:Using CHIP technique we screened the microRNAs which were dys-regulated in hippocampus of transgenic mice of AD, and using a sensitive qRT-PCR platform we further validated the differentially expressed microRNAs. Results: The data revealed a total of 5 miRNAs (cut-off>1⁄42.0 folds) were differentially expressed in hippocampus of AD transgenic mice, including four up-regulated miRNAs, miR-34a, miR-5625, miR5130 and miR-1950, and one down-regulated miRNA, miR-882. Conclusions: Combined with literature and bioinformatics analysis, the data revealed how the deregulated brain microRNAs may be involved in the pathological processes and neurobehavioral abnormalities such as amyloid processing, synaptic loss and anxiety, and memory loss. Acknowledgements: This work was supported by Shenzhen Special Fund Project on Strategic Emerging Industry Development (JCYJ20130329103949650), Medical Scientific Research Foundation of Guangdong Province (A2013598), and Shenzhen Scheme of Science and Technology (Medicine and Health) (201302148).