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P1‐072: Aging transition of perimenopause is associated with bioenergetic shift in the female brain and decline in long‐term potentiation
Author(s) -
Yin Fei,
Yao Jia,
Sancheti Harsh,
Feng Tao,
Mack Wendy J.,
Cadenas Enrique,
Diaz-Brinton Roberta
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.269
Subject(s) - long term potentiation , endocrinology , biology , medicine , bioenergetics , aging brain , endocrine system , synaptic plasticity , neuroplasticity , sirt2 , carbohydrate metabolism , mitochondrion , neuroscience , gene , hormone , microbiology and biotechnology , disease , receptor , genetics , acetylation , sirtuin
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease, forwhich there arevery few therapeutic options available. Previous studies have in a transgenicmousemodel and inhuman serum shown that physical exercise may alter the Ab1-42 (Ab42) level.Methods: In a randomized, controlledmulticenter trial conducted at eight memory clinics in Denmark (the ADEX study), we recruited 200 patients with mild AD to a supervised aerobic exercise group (60-minute exercise sessions three times a week for 16 weeks) or to a control group. The exercise aimed to achieve an intensity of 70-80% of maximal individual heart rate. In a subgroup of subjects (n1⁄437, 24 males/13 females; mean age: 67.2 years +/-6.7, mean MMSE: 24.7 +/5.0), we analysed CSF Ab42 before and after 16 weeks of physical exercise. Analysiswas performedwithMeso Scale Discovery systems. Depending on number of groups, statistical analysis was performed using one-way analysis of variance (ANOVA) or paired t-test. Results: At baseline, mean levels of CSF Ab42 were comparable in the intervention group and in the control group (168 pg/ml and 147 pg/ml, respectively).16 weeks of moderate-to-high intensity physical exercise did not significantly change the CSFAb42 levels in the in intervention group as compared to the control group (p 1⁄4 0.206. However, a non-significant trend was found when comparing delta values (baseline – follow up) for the two groups (p 1⁄4 0.18). Conclusions:We could not detect changes in CSF Ab42 levels of after 16 weeks of moderate-to-high exercise in mild AD patients, which may suggest that 16 weeks of physical exercise cannot reduce cerebral amyloid load.