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P1‐040: Quantitative comparison of dense‐core amyloid plaque burdens in Alzheimer's disease patients and amyloid precursor protein transgenic mice
Author(s) -
Zahs Kathleen R.,
Liu Peng,
Hemmy Laura S.,
Reichl John H.,
Rao Eshaan,
Forster Colleen L.,
Vassar Robert J.,
Borchelt David R.,
Ashe Karen H.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.236
Subject(s) - genetically modified mouse , transgene , hippocampal formation , hippocampus , senile plaques , pathology , amyloid (mycology) , amyloid precursor protein , alzheimer's disease , stereology , presenilin , cortex (anatomy) , medicine , biology , endocrinology , disease , neuroscience , genetics , gene
Thioflavin T fluorescence time course of Ab 40 aggregation in the presence of castalagin, SEN304 and inh3, left, and AFM images of each condition after 150h incubation, right (AFM: 6mm 3 6mm scans). The fluorescence level of Ab 40 (green) is decreased by a factor of 4 with SEN304 and castalagin (red and orange), and by a factor of 2 in the presence of inh3 (yellow). These results were confirmed by AFM imaging : sparse protofibres could be seen with inh3 but no networks of mature fibres were formed, while no more fibres were observed in the presence of SEN304 and castalagin. P1-040 QUANTITATIVE COMPARISON OF DENSE-CORE AMYLOID PLAQUE BURDENS IN ALZHEIMER’S DISEASE PATIENTS AND AMYLOID PRECURSOR PROTEIN TRANSGENIC MICE Kathleen R. Zahs, Peng Liu, Laura S. Hemmy, John H. Reichl, Eshaan Rao, Colleen L. Forster, Robert J. Vassar, David R. Borchelt, Karen H. Ashe, University of Minnesota, Minneapolis, MN, USA; University of Minnesota, Minneapolis, MN, USA; Northwestern University, Chicago, IL, USA; University of Florida, Gainesville, FL, USA; Veterans Administration Medical Center, Minneapolis, MN, USA. Contact e-mail: zahsx001@umn.edu