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P1‐037: Gene transfer of both app and ps1 induces hippocampal impairments close to human early phases of Alzheimer's disease
Author(s) -
Audrain Mickael,
Fol Romain,
Dutar Patrick,
Potier Brigitte,
Billard Jean-Marie,
Flament Julien,
Alves Sandro,
Burlot Marie-Anne,
Dufayet-Chaffaud Gaelle,
Bemelmans Alexis-Pierre,
Valette Julien,
Deglon Nicole,
Hantraye Philippe,
Cartier Nathalie,
Braudeau Jérome
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.233
Subject(s) - hippocampal formation , transgene , amyloid precursor protein , atrophy , senile plaques , hippocampus , neuroscience , genetically modified mouse , dementia , hyperphosphorylation , disease , alzheimer's disease , biology , medicine , microbiology and biotechnology , gene , phosphorylation , genetics
hypothesize regional specific interactions between biomarkers. Methods: McGill-R-Thy1-APP rat (n1⁄49) and wild type (wt; n1⁄412) had [F]FDG and structural MRIs scans at 11-month (baseline) and 16-month (follow-up). Structural images were acquired using a Bruker 70/30USR Biospect MRI (FISP; TE/TR: 2.5/ 5.0ms; FOV: 3.6cm; isotropic 250um voxels; 8 angles). Voxelbased morphometry was performed to obtain longitudinal deforma-