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P1‐023: Cardiorespiratory capacity correlates with cerebral blood flow, white matter hyperintensities, and cognition in preclinical Alzheimer's disease
Author(s) -
Boots Elizabeth A.,
Schultz Stephanie A.,
Oh Jennifer M.,
Dougherty Ryan J.,
Edwards Dorothy Farrar,
Einerson Jean A.,
Korcarz Claudia E.,
Rowley Howard A.,
Bendlin Barbara B.,
Asthana Sanjay,
Sager Mark A.,
Hermann Bruce P.,
Johnson Sterling C.,
Stein James H.,
Cook Dane B.,
Okonkwo Ozioma C.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.219
Subject(s) - cardiorespiratory fitness , hyperintensity , cerebral blood flow , posterior cingulate , cardiology , medicine , neuroimaging , psychology , effects of sleep deprivation on cognitive performance , alzheimer's disease , physical therapy , cognition , physical medicine and rehabilitation , magnetic resonance imaging , disease , neuroscience , radiology
Background: Stress has been associated with cognitive decline. Wewill test the hypothesis that the two factors (coping and distress) of the 14-item Perceived Stress Scale (PSS) differentially predict time to amnestic mild cognitive impairment (aMCI) onset in older adults with normal cognition. Methods:We identified community residing older adults with baseline normal cognition from the Einstein Aging Study and followed them with annual assessments for aMCI onset, as defined by the Peterson criteria. The first wave where participants had normal cognition and had PSS results was considered baseline for these analyses. Multivariable Cox regression analyses were conducted to examine the relationship between baseline PSS score and subsequent onset of aMCI. Results: We followed 582 individuals (mean baseline age 79.3 years) over an average of 3.6 years of follow-up (SD1⁄42.4); 75 (12.9%) participants developed incident aMCI. Cox regression analyses showed that the poor coping group (top quintile of coping factor) had a statistically significant increase in risk of aMCI (p1⁄40.043; HR1⁄41.71; 95% CI:1.02-2.88), compared to subjects in the usual coping group (bottom 4 quintiles) after adjusting for the distress factor, age, gender, race, and years of education. Poor coping trended towards being a significant risk for developing aMCI after additional adjustments for baseline cognitive status and depression (p1⁄40.069; HR1⁄41.63; 95% CI:0.96-2.78). High levels of distress did not predict incident aMCI in any model. Conclusions: Poor coping was associated with an increased risk of incident aMCI among older adults. Interventions targeting coping skills should be tested for their ability to reduce the risk of aMCI onset.