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P1‐018: Association of Alzheimer's genetic risk factors with cognitive decline: The path through life project
Author(s) -
Andrews Shea J.,
Das Debjani,
Anstey Kaarin J.,
Easteal Simon
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.214
Subject(s) - episodic memory , cognitive decline , cognition , psychology , effects of sleep deprivation on cognitive performance , genome wide association study , dementia , gerontology , medicine , disease , single nucleotide polymorphism , genetics , psychiatry , biology , genotype , gene
for people with dementia, residing in the community or in supportive care settings. We performed meta-analyses with hazard ratios (HRs) of various predictors using random effects models. Data on predictors that were not included in our meta-analysis were analyzed descriptively. To explain variability between studies, we stratified the HRs of LTC placement by several study related variables (such as country or type of the study, etc.). Results:The full-text of 341 papers were reviewed and 58 were included in our systematic review. Data from 31 papers were used to pool the HRs of LTC placement for the following predictors: age, gender, ethnicity, marital status, type of dementia, living arrangement of the person with dementia and relationship to their caregiver, caregiver’s age and gender, caregiver’s depression levels. White patients (HR1⁄41.52, 95% CI: 1.22-1.81) who were older (1-year increase in age) (HR1⁄41.02, 95% CI: 1.01-1.03) had an increased risk of institutionalization, while patients with a spouse caregiver (HR1⁄40.56, 95% CI: 0.41-0.89) and living with their caregiver (HR1⁄40.66, 95% CI: 0.50-0.82) had a lower risk of institutionalization. Patient age and type of dementia, caregiver gender, age and level of depression were not significant predictors of institutionalization in people with dementia. Conclusion:Our analyses summarize the impact that patient, caregiver and system factors have on institutionalization of patients with dementia. Defining risk groups and identifying modifiable risk factors for early institutionalization are important steps in increasing the efficiency of resource management in dementia care.