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P1‐017: Predictors of institutionalization in dementia: A systematic review and meta‐analysis
Author(s) -
Cepoiu-Martin Monica,
Patten Scott,
Maxwell Colleen,
Tam-Tham Helen,
Hogan David
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.213
Subject(s) - dementia , institutionalisation , meta analysis , hazard ratio , gerontology , marital status , depression (economics) , population , medicine , ethnic group , random effects model , psychology , demography , clinical psychology , psychiatry , confidence interval , disease , environmental health , sociology , anthropology , economics , macroeconomics
Information Criteria. All models included baseline age and education as covariates. Results: Performance on attentional control declined over time, and the magnitude of decline did not interact with APOE or family history. Importantly, high baseline levels of tau were associated with significantly increased declines in attentional control. In contrast, levels of Ab42 significantly predicted baseline differences in attention but did not moderate decline over time. Conclusions:Attentional control is a sensitive indicator of preclinical AD pathology. Baseline levels of Ab42 predicted cognitive performance at the baseline assessment and baseline levels of tau significantly predicted the rate of cognitive decline. These findings suggest that attention based tasks can serve as both a screening tool (detect baseline difference due to preclinical amyloid pathology) and also as a cognitive endpoint for treatment outcomes (sensitive to cognitive declines over time associated with tau levels).