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IC‐P‐170: Interaction between 18 F‐THK5317, 18 F‐flutemetamol SUVR and cortical thickness
Author(s) -
Doré Vincent,
Bourgeat Pierrick,
Fripp Jurgen,
Macaulay Lance,
Ames David,
Ellis Kathryn A.,
Martins Ralph N.,
Masters Colin L.,
Salvado Olivier,
Villemagne Victor L.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.193
Subject(s) - hippocampus , hippocampal formation , cortex (anatomy) , cerebral cortex , temporal lobe , cerebellum , fusiform gyrus , atrophy , pathology , nuclear medicine , neuroscience , medicine , chemistry , psychology , epilepsy , cognition
-0.021mm/yr, p1⁄40.02) and the PPC (-0.033mm/yr vs. -0.016mm/yr, p1⁄40.007). When controlling for baseline Ab burden as a continuous variable, the differences between Ab+ BDNF and Ab+ BDNF remained strong but did not reach significance (p<0.06). Significantly faster atrophy was also found in Ab+ compared to Abin all regions examined.Conclusions:BDNF was associated with faster cortical loss in the Ab+ group, suggesting an early and interactive effect of Ab and BDNF on neurodegeneration.