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Dementia incidence declined in African‐Americans but not in Yoruba
Author(s) -
Gao Sujuan,
Ogunniyi Adesola,
Hall Kathleen S.,
Baiyewu Olusegun,
Unverzagt Frederick W.,
Lane Kathleen A.,
Murrell Jill R.,
Gureje Oye,
Hake Ann M.,
Hendrie Hugh C.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1894
Subject(s) - yoruba , dementia , incidence (geometry) , cohort , demography , medicine , confidence interval , gerontology , cohort study , disease , philosophy , linguistics , physics , sociology , optics
Abstract Introduction To compare dementia incidence of African‐American and Yoruba cohorts aged ≥70 years enrolled in 1992 and 2001. Methods African‐Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2–3 years until 2009. The cohorts consist of 1440 African‐Americans, 1774 Yoruba in 1992 and 1835 African‐Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years. Results In African‐Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6% (95% confidence interval [CI], 3.2%–4.1%) in the 1992 cohort and 1.4% (95% CI, 1.2%–1.7%) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts. Discussion Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.