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P4‐172: S 44858, a positive allosteric modulator of ampa receptors and GluN2B selective nmda receptors antagonist, prevents the disruption of synaptic plasticity induced by Aβ oligomers
Author(s) -
Danober Laurence,
Rönicke Raik,
Reymann Klaus,
Ondrejcak Tomas,
Zhang Dainan,
Hu Neng-Wei,
Rowan Michael J.,
Desos Patrice,
Cordi Alex,
Lestage Pierre
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1879
Subject(s) - long term potentiation , ampa receptor , nmda receptor , schaffer collateral , excitatory postsynaptic potential , chemistry , synaptic plasticity , postsynaptic potential , ltp induction , stimulation , long term depression , glutamate receptor , receptor , pharmacology , neuroscience , biology , biochemistry
P4-172 S 44858, A POSITIVE ALLOSTERIC MODULATOR OFAMPA RECEPTORS AND GLUN2B SELECTIVE NMDA RECEPTORS ANTAGONIST, PREVENTS THE DISRUPTION OF SYNAPTIC PLASTICITY INDUCED BYAb OLIGOMERS Laurence Danober, Raik R€onicke, Klaus Reymann, Tomas Ondrejcak, Dainan Zhang, Neng-Wei Hu, Michael J. Rowan, Patrice Desos, Alex Cordi, Pierre Lestage, Pôle Innovation Th erapeutique Neuropsychiatrie, Institut de Recherches Servier, Croissy-sur-Seine, France; Leibniz Institute for Neurobiology, Magdeburg, Germany; Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland; Pôle Expertise Recherche et Biopharmacie, Institut de Recherches Servier, Suresnes, France. Contact e-mail: Laurence.danober@fr.netgrs.com