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IC‐P‐162: Entorhinal, parahippocampal, and inferior temporal F18‐T807 SUVR correlates with CSF total tau and tau T181P in cognitively normal elderly
Author(s) -
Chhatwal Jasmeer P.,
Schultz Aaron P.,
Marshall Gad A.,
Boot Brendon,
Gomez-Isla Teresa,
Dumurgier Julien,
LaPoint Molly,
Scherzer Clemens,
Roe Allyson D.,
Hyman Bradley T.,
Sperling Reisa A.,
Johnson Keith A.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.185
Subject(s) - tauopathy , radioligand , tau protein , tau pathology , cerebrospinal fluid , medicine , entorhinal cortex , neuroscience , pathology , endocrinology , hippocampus , psychology , alzheimer's disease , disease , receptor , neurodegeneration
variant primary progressive aphasia showed asymmetric binding in the left inferior frontal and parietal cortex (Figure 2). Tracer binding was unexpectedly seen in all 3 patients with FTD due to presumed tau-negative, TDP43-posistive inclusions, particularly in degenerating white matter (Figure 3). 1/2 patients at risk for CTE showed focal AV1451 binding in the left anterior temporal lobe (Figure 4). Conclusions:AV1451 uptake largely conformed to the expected distribution of pathology in non-AD tauopathies, though subcortical signal overlapped with binding in NC. Unexpected AV1451 uptake was also found in patients with presumed tau-negative, FTD-TDP pathology. PET-to-autopsy correlation studies are needed to better characterize these findings.