IC‐P‐162: Entorhinal, parahippocampal, and inferior temporal F18‐T807 SUVR correlates with CSF total tau and tau T181P in cognitively normal elderly

variant primary progressive aphasia showed asymmetric binding in the left inferior frontal and parietal cortex (Figure 2). Tracer binding was unexpectedly seen in all 3 patients with FTD due to presumed tau-negative, TDP43-posistive inclusions, particularly in degenerating white matter (Figure 3). 1/2 patients at risk for CTE showed focal AV1451 binding in the left anterior temporal lobe (Figure 4). Conclusions:AV1451 uptake largely conformed to the expected distribution of pathology in non-AD tauopathies, though subcortical signal overlapped with binding in NC. Unexpected AV1451 uptake was also found in patients with presumed tau-negative, FTD-TDP pathology. PET-to-autopsy correlation studies are needed to better characterize these findings.