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P4‐138: Patterns of later‐life depression are differentially associated with decline in cognitive domains
Author(s) -
Gillis Jennifer Cai,
Chang Shun-Chiao,
Devore Elizabeth,
Rosner Bernard,
Grodstein Fran,
Okereke Olivia I.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1844
Subject(s) - depression (economics) , cognition , verbal fluency test , memory span , psychology , recall , clinical psychology , cognitive decline , psychiatry , medicine , dementia , neuropsychology , working memory , disease , economics , cognitive psychology , macroeconomics
concentrations and MCI in a population-based study sample aged 50-80 years. Methods: From the second examination of the Heinz Nixdorf Recall study, 489 participants with MCI (66.0467.8 years; 44% men; amnestic MCI (aMCI) n1⁄4248; non-amnestic MCI (naMCI) n1⁄4241) and 1,300 cognitively normal (CN; 63.0067.8 years; 47% men) participants free of cardiac diseases were included in the analyses. All participants performed a validated brief cognitive assessment. MCI was diagnosed according to previously published MCI criteria. NT-proBNP levels were stratified according to the threshold suggested by the European Society of Cardiology (> 125 pg/ ml) for the diagnosis of heart failure in subjects with non-acute dyspnoe. Log-Poisson regression models (adjusted for sociodemographic/cardiovascular risk factors) resulting in prevalence rate ratios (PRR) and 95% confidence intervals (CI) were calculated to determine the association of MCI and its subtypes with NT-proBNP. Results: MCI participants showed significantly higher NT-proBNP values in comparison to CN participants (174.886216.71 vs. 120.696144.12 pg/ml, p<0.001). Using MCI as outcome variable, the crude PRR for participants with NT-proBNP-levels > 125pg/ml in comparison to participants with levels 125pg/ml was 1.73 (1.45-2.07; fully adjusted: 1.27 (1.03-1.56)). For aMCI, the crude PRR was 1.82 (1.422.34; fully adjusted: 1.35 (1.00 -1.81)) and 1.98 (1.66-2.37; fully adjusted: 1.34 (1.09-1.66)) for naMCI. There was no difference in PRR between MCI subtypes in the gender-stratified models. Conclusions: Our results suggest an association of NT-proBNP with MCI and both MCI subtypes. As this is a cross-sectional analysis we cannot state that high NT-proBNP concentrations increase the risk for MCI. However, our longitudinal follow-up will allow us to further elucidate this relationship.