P4‐130: Apolipoprotein e polymorphism distribution among filipino elderly community dwellers

intramuscular thigh (IT), and subcutaneous thigh (ST). We created sex and CT scanner specific quintiles for each adipose tissue region; all analyses were stratified by sex. Cognition was measured with the modified mini-mental status examination (3MS) in years 1, 3, 5, 8, 10, and 11. Incident dementiawas defined bymedical records, medication use, and cognitive change (>1.5SD). We used linear mixedeffects models to assess cognitive decline and Cox proportional hazards models to assess dementia-free survival. Adjusted models controlled for age, race, education, literacy, APOE e4, CT scanner, hypertension, diabetes, smoking, physical activity, body mass index (BMI), and region-specific adipose tissue area. Estimates for the highest quintile along with the p-value for a test for trend across quintiles are reported. Results: Higher density adipose tissue was associated with lower BMI, less hypertension and diabetes, higher physical activity, more smoking, and APOE e4. In women, the highest quintile of SAwas associated with 0.28 point/year more decline in 3MS slope compared with lowest quintile (p1⁄40.002). We found similar results for VA (-0.25, p1⁄40.05) and IT (-0.32, p1⁄40.005). Similarly, higher quintiles of SA, IT, and ST were associated with elevated risk for dementia in women (SA: Hazard Ratio1⁄41.62 p1⁄40.01; IT: HR1⁄42.24, p1⁄40.003; ST: HR1⁄41.43, p1⁄40.01). In men, we found an elevated risk of dementia associated with higher levels of VA (HR 1⁄4 2.00, p1⁄40.03) but no significant associations with cognitive decline in men. Conclusions:Higher adipose tissue density in multiple regions was consistently associated with worse cognitive outcomes in women.