Premium
P4‐123: Scopolamine disrupts allocentric spatial navigation in humans: The study in a real‐space analogue of the morris water maze
Author(s) -
Laczó Jan,
Markova Hana,
Gazova Ivana,
Parizkova Martina,
Cerman Jiri,
Andel Ross,
Harrison John,
Windisch Manfred,
Hort Jakub
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1829
Subject(s) - donepezil , morris water navigation task , scopolamine , psychology , spatial memory , placebo , cholinergic , scopolamine hydrobromide , acetylcholinesterase , parasympatholytic , acetylcholinesterase inhibitor , working memory , neuroscience , pharmacology , medicine , muscarinic acetylcholine receptor , cognition , chemistry , dementia , biochemistry , alternative medicine , disease , receptor , pathology , enzyme
included only Moderate/Severe CKD but added duration (years) of CKD. Results: 393 participants [moderate CKD N1⁄4308, mean eGFR1⁄430.6 (10.0); mild CKD N1⁄486 (eGFR1⁄4 49.7 (4.2)] were recruited. Demographics are described in Table 1; moderate/severe vs. mild CKD participants were slightly less educated and had higher systolic BP. The linear association between eGFR and severity of CI (none, mild, moderate, severe) was moderate but significant (rho1⁄4 -.15 P1⁄4 .001). In Model 1 (mod/sev and mild CKD), Black race (AOR 3.5 (1.8, 6.5: p 1⁄4 <.001) and phosphorous level (AOR 1.5 (1.02, 2.1: p 1⁄4 .04) were significantly associated with mod/sev CI. In Model 2 (mod/sev CKD only), age (1.4 (1.07, 2.0: p 1⁄4 .02), male gender (1.9 (1.02, 3.5: p 1⁄4 .04) Black race (5.7(2.5, 12.7: p<.001), phos (1.6 (1.06, 2.5:p1⁄4 .03), and duration of CKD (1.03/year (1.007, 1.06: p 1⁄4 .01) were significant. Conclusions: Age, Black race, male gender, elevated phosphorous and CKD duration were significantly associated with mod/severe CI in Stages 3b-5 CKD. Phosphorous level as a modifiable risk factor, and a threshold effect of CKD duration on risk of CI need further exploration in our future longitudinal analyses.