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P4‐118: Neuropsychological determinants of stage 3 of preclinical Alzheimer disease
Author(s) -
Schindler Suzanne E.,
Jasielec Mateusz S.,
Xiong Chengjie,
Fagan Anne M.,
Morris John C.,
Hassenstab Jason
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1824
Subject(s) - clinical dementia rating , dementia , episodic memory , psychology , neuropsychology , cognition , alzheimer's disease , disease , hazard ratio , medicine , clinical psychology , psychiatry , confidence interval
examination waves (t1:1993/94; t2:1997/98; t3:2005/07). For data analysis, subjects with MCI (29% at t3) and AD (7% at t3) were contrasted with healthy controls. Diagnostic groups were dichotomized according to school education as a proxy for CR. Results:Patients with MCI and AD showed a significantly lower performance in all cognitive domains considered with a continuous decline during the follow-up period when compared with the healthy controls. As demonstrated by repeated measures ANOVAs, these effects were more pronounced in patients with a low than a high CR in verbal fluency, abstract thinking, and visuospatial abilities. Conclusions:Our results confirm the concept of CR and demonstrate that CR primarily corresponds to verbal fluency, abstract thinking, visuospatial abilities rather than attention and declarative memory. It is suggested that CR conserves aspects of executive functioning rather than cognitive performance in general.