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P4‐110: Semantic memory manifestations in normal aging and parkinson's disease and their implications to the embodied cognition theory
Author(s) -
Carthery-Goulart Maria Teresa,
Silva Henrique Salmazo,
Guimarães Rocha Maria Sheila,
Baradel Roberta Roque,
Godinho Fabio,
Cravo Andre,
Sato João Ricardo,
Mattos Pimenta Parente Maria Alice
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1816
Subject(s) - verb , psychology , semantic memory , comprehension , noun , embodied cognition , cognition , cognitive psychology , boston naming test , semantic dementia , verbal fluency test , dementia , affect (linguistics) , association (psychology) , linguistics , disease , medicine , neuropsychology , communication , frontotemporal dementia , neuroscience , computer science , artificial intelligence , pathology , philosophy , psychotherapist
3.27/12.81, respectively. We retrospectively analyzed the prevalence, conversion rate to dementia, and neurobehavioral background among the participants in the Kurihara project. Methods: 1) The database of 513 participants aged 75+ years in the Kurihara Project was analyzed according to the following criteria: cognitive complaints as the GDS-15 item; 1 SD below the mean gait speed by the maximum speed; no dementia or ADL disability by CDR 0/0.5 and DSM-IV. 2) Conversion rates to dementia (3-5 years) from the MCR/Non-MCR groups were calculated. 3) Neurobehavioral backgrounds were investigated using the executive test scores of TrailMaking Tests and Digit Symbol, and MRI-based diagnoses of very mild Alzheimer’s disease (AD) or subcortical vascular dementia (SVD). Results: 1) We found 57 participants that met the criteria for MCR syndrome (11.1%). 2) No group difference was noted for conversion to dementia. The effect of CDR was higher than that of MCR .3) One-way ANCOVA with the covariance of MMSE revealed decreased scores on TMT-A and Digit Symbol in the MCR group. No diagnostic differences were noted for very mild AD or SVD. Conclusions: Our calculated prevalence value for MCR was within the CI of Verghese et al. However, there were no significant differences in the incidence of dementia or the neurological background. We considered executive dysfunction as a surrogate marker of MCI. As TMT-A or Digit symbol test were at the upper extremities, maximum gait velocity was at the lower extremity.