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IC‐P‐158: A multiscale MRI approach to investigate novel drug treatment strategies in mouse models of Alzheimer's disease
Author(s) -
Ismail Ozama,
Holmes Holly,
Colgan Niall,
Ma Da,
Wells Jack A.,
Powell Nicholas M.,
O'Callaghan James M.,
Harrison Ian F.,
Walker-Samuel Simon,
Cardoso Jorge M.,
Modat Marc,
Fisher Elizabeth,
Ourselin Sebastien,
Murray Tracey K.,
Ahmed Zeshan,
O'Neill Michael J.,
Johnson Ross A.,
Collins Emily C.,
Lythgoe Mark F.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.181
Subject(s) - doxycycline , diffusion mri , medicine , atrophy , pathological , drug development , magnetic resonance imaging , pathology , nuclear medicine , neuroscience , psychology , drug , pharmacology , chemistry , radiology , biochemistry , antibiotics
described effects of age on clinical presentation (greater memory impairment in older patients, diffuse cortical deficits in younger patients) and neurodegenerative patterns (medial temporal in lateonset AD and cortical-predominant in early-onset AD). ApoE-ε4 carriers had greater right-parietal and bilateral lateral-temporal retention than non-carriers. Lower MMSE scores predicted greater uptake in inferior/middle frontal gyri and left-temporal pole, consistent with spread of tau into anterior brain regions with advancing disease. These results remained largely unchanged when age, ApoE-ε4 and MMSE were included in a combined model. Decreased performance on modified trailmaking, figure copy, and figure recall tasks was related to increased uptake in right-occipitoparietal visual association cortex, and impaired figure recall also predicted tracer retention in right>left hippocampus (Figure 3). Conclusions:We found preliminary associations between [F]AV1451 binding patterns and age, ApoE-ε4 and domain-specific cognitive performance, mirroring links between these factors and the distribution of neurofibrillary tangles at autopsy. These findings need to be confirmed in larger samples.