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P4‐073: A quantitative comparison between two manual hippocampal segmentation protocols
Author(s) -
Zandifar Azar,
Fonov Vladimir,
Coupé Pierrick,
Pruessner Jens C.,
Collins D. Louis
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1778
Subject(s) - harp , segmentation , hippocampal formation , protocol (science) , computer science , kappa , artificial intelligence , pattern recognition (psychology) , medicine , pathology , mathematics , physics , alternative medicine , geometry , quantum mechanics
ERC and ADAS13 scores were 35%, 30% and 7%. Thirty-eight (38) CN subjects progressed to incident MCI, but neither age nor education predicted progression. In univariate Cox models, ADAS13 score (c1⁄414.2, p<.0001) and ERC normalized volume (c1⁄46.2, p1⁄40.01) predicted progression, while amyloid SUVR showed a trend toward significant prediction (c1⁄43.2, p1⁄4.07). In multivariate Cox regression, only ADAS13 scores predicted progression (c 1⁄48.3, p1⁄4.004). Using dichotomized variables, all predictors were significant in univariate analyses, but none provided unique variance in multivariate models. The estimated 2.1 year progression rates to MCI and 95% CIs were: