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P4‐061: Amyloid deposition disrupts local and distant glucose metabolism
Author(s) -
Brier Matthew R.,
McCarthy John E.,
Friedrichsen Karl,
Benzinger Tammie L.S.,
Bateman Randall,
Su Yi,
Morris John C.,
Ances Beau
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1766
Subject(s) - amyloid (mycology) , univariate , carbohydrate metabolism , correlation , multivariate statistics , alzheimer's disease , bayesian multivariate linear regression , biology , neuroscience , medicine , linear regression , endocrinology , disease , mathematics , pathology , statistics , geometry
paradigm. Results: Fig. 2 shows group ICA map of the PON, encompassing primary olfactory cortex (POC), hippocampus, insula, striatum, and putamen and the DMN. The temporal behavior of PON showed a higher degree of variability in AD. Both ICA maps showed significantly less fMRI activation in aMCI and AD groups, following a similar descending trend of the UPSIT scores and the PON responsiveness in Fig. 3. Most interestingly, while the responsiveness of PON in aMCI is significantly lower than CN and different from AD under no-odor condition, aMCI and AD showed the same level of responsiveness under the odor condition. This result indicates that olfactory dysfunction detected by odor stimulations in aMCI has reached to a level comparable to AD. Conclusions: The olfactory fMRI paradigm provided a straightforward method to detect functional degeneration in the olfactory and DMN networks. A striking deterioration in the responsiveness of the PON and DMN is demonstrated in aMCI and AD. By delineating the neural substrate of AD clinical presentations, olfactory fMRImay provide an objective marker for the early diagnosis.