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P4‐054: White matter changes in cognitively intact older adults with informant ratings of cognitive decline
Author(s) -
Chang Yu-Ling,
Yen Yu-Shiuan,
Chen Pei-Cing,
Zhuo Yi-Yuan,
Tseng Wen-Yih
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1759
Subject(s) - fractional anisotropy , white matter , psychology , cingulum (brain) , clinical dementia rating , cognition , cognitive decline , posterior cingulate , audiology , clinical psychology , dementia , developmental psychology , cognitive impairment , medicine , psychiatry , magnetic resonance imaging , disease , radiology
multi-domain SCI subjects progressed to mild cognitive impairment or dementia at seven, five and two years, respectively. Conclusions:Our results indicate that 1) the different SCI categories have different clinical prognoses and biomarker signatures, 2) longitudinally followed CN subjects are needed to establish clinical cut-offs, 3) SMCsubjects present brain atrophy and 4) pattern-based analyses outperform commonly-used single ROI-based neuroimaging biomarkers are needed to detect initial stages of cognitive impairment.