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P4‐044: Feasibility of a cognitive rehabilitation group program for patients with mild dementia in Alzheimer's disease: A randomized, controlled, single‐blinded pilot study
Author(s) -
Ochmann Sina Luisa,
Kasper Elisabeth,
Hoffmann Wolfgang,
Schneider Wolfgang,
Teipel Stefan J.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1748
Subject(s) - rehabilitation , physical therapy , cognitive rehabilitation therapy , dementia , randomized controlled trial , quality of life (healthcare) , cognition , psychology , psychoeducation , intervention (counseling) , physical medicine and rehabilitation , medicine , disease , psychiatry , psychotherapist , surgery , pathology
only age was independently significant (b1⁄4-.54, p<.01). Conclusions:A 12-week moderate intensity walking intervention leads to significantly improved fitness in both MCI and HOA. The change in fitness (VO2Peak-DR) was associated with robust cortical thickness increases in bilateral and multiple brain regions, which was not differentiated by cognitive status or ε4 inheritance. These preliminary findings suggest improved fitness may lead to increased cortical thickness in older adults regardless of cognitive status or ε4 inheritance. Thus, regular exercise may be an especially beneficial intervention to counteract cortical atrophy in all risk groups, and may provide protection against future cognitive decline in both HOA and older adults who have begun to experience cognitive decline.