Premium
P4‐036: CSF Alzheimer's disease‐related biomarkers are higher in subjects with periodontal disease
Author(s) -
Kamer Angela R.,
Pirraglia Elizabeth,
Li Yi,
Tsui Wai,
McHugh Pauline,
Svetcov Spencer,
Linker Ross,
Annam Kumar,
Osorio Ricardo,
Glodzik Lidia,
Corby Patricia M.,
Janal Malvin,
Zetterberg Henrik,
Blennow Kaj,
DeLeon Mony
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1740
Subject(s) - pathogenesis , medicine , cerebrospinal fluid , disease , apolipoprotein e , periodontal disease , amyloid beta , gastroenterology , pathology , alzheimer's disease , immunology
cognitive performance in “normal” individuals may therefore provide evidence of disease progression. Using a cohort of aging cognitively intact individuals with a first-degree family history of AD, we evaluated performance in several cognitive domains in relation to AD biomarkers and APOEe4 status. Methods:Baseline data were acquired for an ongoing prevention trial nested in the PREVENT-AD program. After screening for cognitive disorder using the Montreal Cognitive Assessment and the Clinical Dementia Rating, we obtained neuropsychological performance measures using the Repeatable Battery for Assessment of Neuropsychologic Status (RBANS), which evaluates 5 cognitive domains (immediate memory, delayed memory, attention, language and visuospatial/ constructional) as well as global cognition. Cerebrospinal fluid (CSF) was obtained by lumbar puncture, and protein concentrations were measured using Innotest technology for tau, P-tau and Ab142, and using ELISA for apolipoprotein E.Results:Baseline RBANS scores were within the normal range for age and education but were lower in all domains in older subjects (n1⁄4235; p<0.0005). Higher levels of CSF tau, P-tau, apoE and tau/Ab1-42 ratio (n1⁄485) were associated with lower global cognitive performance and with lower scores in several domains. In APOEe4+ individuals (n1⁄428), tau and P-tau were inversely correlated with attention, delayed memory and global cognition. In the remainder (n1⁄457), we observed a relationship only with language (inverse correlation with tau, P-tau, and apoE) and attention scores (inverse correlation with Ab1-42 and ratio of tau/Ab1-42 (Ab r1⁄4 -0.3, p1⁄40.03; ratio r1⁄4-0.4, p1⁄40.02). Conclusions: Tau and P-tau, recognized biomarkers of neuronal injury, were associated with cognitive scores in a cognitively “normal” population at risk of AD. As expected, CSF amyloid was weakly related to cognition but, surprisingly, elevated CSF apoE protein was associated with reduced cognitive performance. Most such correlations were evident only in those with APOEe4. Especially in the latter group, the data suggest the presence of on ongoing silent disease process. Forthcoming longitudinal data should further elucidate the role of progressive pathophysiological processes in emerging clinical manifestations of disease.