Premium
P4‐028: The role of fynt tyrosine kinase in astrocytes pertaining to neuroinflammation in Alzheimer's disease
Author(s) -
Lee Chingli,
Wei Tan Doris Xiu,
Bei Low Clara Ying,
Peng Lai Mitchell Kim,
Khim Tan Michelle Guet
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1732
Subject(s) - neuroinflammation , fyn , proinflammatory cytokine , biology , tumor necrosis factor alpha , astrocyte , tyrosine kinase , signal transduction , microbiology and biotechnology , microglia , cancer research , endocrinology , immunology , inflammation , central nervous system
the group of the inflammatory caspases; until now, it has not been characterized its expression in the human brain.Methods:Post mortem tissue from temporal cortex of different dementias including AD was analyzed by confocal microscopy combined with quadruple and triple immunostaining with antibodies raised to phospho tau protein, caspase-5 and Aß peptide. Results:We found strong caspase-5 immunoreactivity associated mainly with the soluble extracellular Aß deposits in AD brains. Also caspase-5, was mainly expressed in brain blood vessels, that had intra and extracellular soluble Aß peptide deposits. We do not detected colocalization of this enzyme with tau protein. Caspase-5 expression and colocalization with soluble Aß was only observed in AD brain but not in other taupathies. Conclusions: Is suggested that these deposits and caspase 5 could be triggering neuroinflammation, therefore caspase 5 maybe a specific marker of inflammation in AD brains.