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P4‐013: Perturbation of 3R/4R tau ratio impairs app axonal transport in neurons derived from human embryonic stem cells (HESC)
Author(s) -
Lacovich Valentina,
Alloatti Matias,
Avale Maria Elena,
Espindola Sonia,
Falzone Tomas,
Čarna Maria,
Krell-Roesch Janina,
Forte Giancarlo,
Geda Yonas E.,
Stokin Gorazd B.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1717
Subject(s) - embryonic stem cell , neuroscience , axoplasmic transport , microbiology and biotechnology , biology , chemistry , biochemistry , gene
association of the AD risk allele “T” of rs6733839, located near the Bridging integrator 1 (BIN1) gene, with this phenotype. Controlling for demographic (age, sex, and education) covariates, carriers of the “TT” genotype performed significantly worse (p1⁄40.005, p1⁄40.001 among Ashkenazi origin) in episodic memory compared to carriers of the “C” allele (“CC” and “TC”). When including additional potential covariates (clinical and APOE4 carriership status), results remained highly significant (p1⁄40.007, p1⁄40.001 among Ashkenazi). Interestingly, as validated in multiple large studies, BIN1 is one of the most established AD risk locus, with a high odds-ratio. Conclusions:Taken together, BIN1 may contribute to individual differences in memory performance among T2D individuals.