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P4‐004: Cardiorespiratory capacity modifies the association between a polygenic risk score and CSF biomarkers in preclinical Alzheimer's disease
Author(s) -
Schultz Stephanie A.,
Boots Elizabeth A.,
Dougherty Ryan J.,
Darst Burcu F.,
Yu Sherman,
Kirby Taylor,
Edwards Dorothy Farrar,
Einerson Jean A.,
Korcarz Claudia E.,
Zetterberg Henrik,
Blennow Kaj,
Carlsson Cynthia M.,
Bendlin Barbara B.,
Asthana Sanjay,
Sager Mark A.,
Hermann Bruce P.,
Johnson Sterling C.,
Stein James H.,
Engelman Corinne D.,
Cook Dane B.,
Okonkwo Ozioma C.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1708
Subject(s) - cardiorespiratory fitness , apolipoprotein e , medicine , oncology , framingham risk score , disease , cohort , genome wide association study , cerebrospinal fluid , risk factor , endocrinology , single nucleotide polymorphism , genotype , biology , genetics , gene
P4-004 CARDIORESPIRATORY CAPACITY MODIFIES THE ASSOCIATION BETWEEN A POLYGENIC RISK SCORE AND CSF BIOMARKERS IN PRECLINICAL ALZHEIMER’S DISEASE Stephanie A. Schultz, Elizabeth A. Boots, Ryan J. Dougherty, Burcu F. Darst, Sherman Yu, Taylor Kirby, Dorothy Farrar Edwards, Jean A. Einerson, Claudia E. Korcarz, Henrik Zetterberg, Kaj Blennow, Cynthia M. Carlsson, Barbara B. Bendlin, Sanjay Asthana, Mark A. Sager, Bruce P. Hermann, Sterling C. Johnson, James H. Stein, Corinne D. Engelman, Dane B. Cook, Ozioma C. Okonkwo, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA, University of Wisconsin-Madison, Madison, WI, USA, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA, Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, M€olndal, Sweden, Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, Madison, WI, USA, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA. Contact e-mail: sschultz@medicine.wisc.edu