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P3‐317: Hippocampal CYP46A1 overexpression is beneficial in rodent models of Alzheimer's disease
Author(s) -
Alves Sandro,
Lamazière Antonin,
Audrain Mickael,
Braudeau Jérome,
Fouquet Françoise,
Aubourg Patrick,
Cartier Nathalie
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1691
Subject(s) - western blot , hippocampal formation , hippocampus , cholesterol , biology , medicine , microbiology and biotechnology , endocrinology , biochemistry , gene
for the gamma. Conclusions:Predicted treatment effects based on normal or chi-square distributions may show greater progression and less variability than those based on gamma distributions. While the results are similar between normal and chi-square distributions, the latter may be preferred on statistical and clinical grounds: 1) it has fewer parameters to evaluate; 2) it allows for a more realistic distribution of declines over time, where a few patients may fail or worsen more markedly than would be predicted by the former.