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P3‐300: Combination therapy of cholinesterase inhibitor plus memantine for behavioral and psychological symptoms in Alzheimer's disease patients
Author(s) -
Shin Cheol-Seung
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1673
Subject(s) - memantine , psychology , dementia , activities of daily living , medicine , alzheimer's disease , psychiatry , disease
Background:To compare the effectiveness of combination therapy with cholinesterase inhibitors (ChEI) plus memantine in the treatment of aggression, agitation, and psychosis with older Alzheimer’s disease (AD) patients (age >75 years). Methods: We compared the clinical effects of combination therapy of cholinesterase inhibitors (ChEI) plus memantine (n1⁄450) in all AD patients with behavioral and psychological symptom of dementia (BPSD) (assessed by NPI baseline score). Primary efficacy measure: Neuropsychiatric Inventory (NPI); secondary efficacy measures: Clinical Global Impression (CGI), CohenMansfield Agitation Inventory (CMAI), Mini-Mental State Examination (MMSE) and instrumental activities of daily living (ADL). Results:The addition of memantine resulted in stabilization of the Mini-Mental State Examination scores for 6 months. NPI scores decreased significantly from baseline to month 6 (P