Premium
P3‐253: Interactions between ApoE ε4 status and hypercholesteremia on response to acetylcholinesterase inhibitor in Alzheimer's disease
Author(s) -
Weng Pei-Hsuan,
Chen Jen-Hau,
Chen Ta-Fu,
Sun Yu,
Wen Li-Li,
Yip Ping-Keung,
Chu Yi-Min,
Chen Yen-Ching
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1626
Subject(s) - apolipoprotein e , acetylcholinesterase , medicine , confidence interval , logistic regression , disease , rivastigmine , dementia , gastroenterology , donepezil , biology , enzyme , biochemistry
association with cognitive impairment in an elderly population from Singapore.Methods:A total of 623Chinese andMalay subjects, whowere recruited into the Epidemiology of Dementia in Singapore Study, underwent extensive neuropsychological tests and brainMRI. Subcortical volumes of the following structures weremeasured using a model-based automated procedure (FreeSurfer v 5.1): accumbens, amygdala, caudate, pallidum, putamen, thalamus and hippocampus. Cognitive functionwas expressed as both composite and domain-specific Z-scores. Regressionmodels were constructed with adjustments for age, sex, race, education and additionally for cardiovascular and MRI markers. Results: Among 623 subjects, 580 participants had gradableMRI scans and hencewere included in the analysis. Inmultivariate adjustedmodels, thedeterminantsof smaller subcortical structure volumes were increasing age, female sex, Malay ethnicity, presenceof lacunesonMRIandwhitematter lesions volume.Furthermore, smaller volumes of accumbens [mean change inZ-scoreperSD decrease in volume: -0.11 (95%CI:-0.17; -0.04), amygdala [mean change in Z-score per SD decrease: -0.13 (95%CI: -0.20; -0.06)], caudate [mean change in Z-score per SD decrease: -0.07 (95%CI: -0.13; -0.01)], putamen [mean change in Z-score per SD decrease: -0.06 (95%CI: -0.12; -0.00)], thalamus [mean change in Z-score per SD decrease: -0.09 (95% CI: -0.15; -0.03)] and hippocampus [mean change in Z-score per SD decrease: -0.10 (95%CI: -0.17; -0.04)] were significantly associated with composite Z-scores. In terms of domain specific analysis, smaller volumes of the subcortical structureswere also associatedwithworse performance on executive function, attention, language, visuoconstruction, visuomotor speed, visual memory and verbal memory. Conclusions: In this Asian population, smaller subcortical structure volumes were significantly associated with cognitive impairment and dementia, suggesting that besides cortical atrophy, subcortical grey matter atrophy is also important in the development of cognitive impairment and dementia.