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P3‐215: Long‐term environmental enrichment protected emotional and cognitive behavioral abnormality of triple transgenic mice of Alzheimer's disease
Author(s) -
Yu Jun,
Sun Qian,
Zhang Yanling,
Xing Renzhong,
Ma Quan,
Xu Hua,
Liu Jianjun,
Yang Xifei
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1587
Subject(s) - open field , behavioural despair test , elevated plus maze , anxiety , depression (economics) , disease , psychology , memory impairment , medicine , cognition , environmental enrichment , pathological , psychiatry , neuroscience , antidepressant , economics , macroeconomics
activity, gait speed, and cognition (Figure 1). Higher initial gait speed predicted slower decline in cognition andwalking activity from year 1 to 10 (ps<.001). Initial cognition and walking activity were not significant cross-domain predictors. After accounting for the predictive effects of the baseline scores, decline in walking, cognition and gait speed were interrelated (ps<.01). In follow-up analyses, the correlation between change inwalking and cognition became non-significant after accounting for changes in gait speed; however, the correlation between change in cognition and change in gait speed was unmitigated after controlling for changes in walking. In a follow-up piece-