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P3‐205: Various progression according to anatomic subtypes of Alzheimer's disease
Author(s) -
Noh Young,
Na Duk L.,
Na Han Kyu,
Kang Dae Ryong
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1577
Subject(s) - dementia , neuropsychology , atrophy , cognition , disease , psychology , medicine , audiology , neuroscience
syndromes of primary progressive aphasia (PPA), language dysfunction is not a defining feature of bvFTD and is generally not emphasised clinically. However, very little information is available concerning neurolinguistic processing in bvFTD. Methods: Key language functions were analysed in a large, comprehensively characterised cohort of patients with bvFTD (n1⁄425) in relation both to healthy older controls (n1⁄424) and a cohort of patients representing core PPA syndromes (progressive nonfluent aphasia and semantic dementia; n1⁄435). Results:Relative to healthy controls, patients with bvFTD showed a profile of neurolinguistic deficits that were less severe than PPA but still extensive, affecting naming, semantic and sentence processing and literacy skills but sparing word repetition. Voxel-based morphometry in the bvFTD cohort revealed a correlated profile of widespread grey matter loss affecting dominant prefrontal, peri-Sylvian and anterior temporal cortices comprising the canonical language network.Conclusions: Language decline may be a significant if under-recognised issue in bvFTD, with implications both for clinical diagnosis and management of these patients and emerging models of language network disintegration in neurodegenerative disease.