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P3‐198: Emotional perception deficits in amyotrophic lateral sclerosis in korea
Author(s) -
Oh Seong-il,
Kim Hee Jin,
Kim Seung Hyun
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1569
Subject(s) - disgust , amyotrophic lateral sclerosis , neuropsychology , psychology , cognition , emotion perception , audiology , facial expression , perception , surprise , emotional expression , spectrum disorder , clinical psychology , developmental psychology , medicine , psychiatry , anger , disease , neuroscience , social psychology , communication , pathology
Background:To assess the usefulness of cognitive function composites (CFC) to discriminate between healthy aging (HA), nonAlzheimer’s disease (non-AD) amnestic Mild Cognitive Impairment (aMCI), and prodromal Alzheimer’s disease (AD). Methods: Two samples of subjects, > 64 years old, were analyzed. The discovery group (DG) was of 59 subjects, recruited from Recercalia project, divided in 39 HA (20 men) and 20 aMCI (12 man). The replication group (RG) was a bigger sample (n1⁄4175), recruited from AB255 study, divided in 42 HA (21 men) and 133 aMCI (64 man). In both groups all aMCI presented storage memory impairment, and no comorbidities that could explain their cognitive impairment. All subjects received an extensive neuropsychological assessment, including CFC’s sensitive to: language, memory, praxis, visual gnosis and executive functions, all with ADN available and APOE genotyped. A PET-PIB scanner, was administered at baseline to the DG, and subjects were divided in PiB+ or PiBwith a cutoff value of PIB1⁄41.5, that is, HA+ (n1⁄4 2), HA(n1⁄437), aMCI+ (n1⁄412), and aMCI(n1⁄48). The HA+ group was excluded from the analysis due to the sample size (n1⁄42). A PET-FDG scanner, was administered at baseline to the RG, and analyzed according to the Alzheimer’s Disease Neuroimaging Initiative (ADNI) methods. The subjects were divided in FDG+ or FDGwith a cutoff value of FDG1⁄41.2, that is, HA (n1⁄442), aMCI+(n1⁄457), aMCI(n1⁄476). The HA group were all FDG-. Results: For the DG, delayed recall on memory (DR), executive and language CFC’s were the best discriminating between, HA-, aMCIand aMCI+ groups. Learning and recognition on memory CFC did significantly discriminate between HA and aMCI whole groups, but not between aMCI+ and aMCIgroups. For the RG all CFC’s but visual gnosis composite, discriminated between HA and aMCI groups on the whole sample. DR on memory and executive CFC’s showed the highest values to discriminate between, HA, aMCIand aMCI+ groups, independently of their APOE-ε4 genotype. Conclusions: A brief neuropsychological battery comprising tests sensitive to fronto-temporal functions, such as memory delayed recall and executive functions may be useful to discriminate between HA, non-AD aMCI and prodomal AD. P3-197 CROSS-VALIDATION AND EXTENSION OF THE LATENT DEMENTIA PHENOTYPE IN THE ADNI DATASET