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P3‐174: Structural connectivity as a biomarker for Alzheimer's disease: Evaluation in a multicenter trial and a primary care cohort
Author(s) -
Teipel Stefan J.,
Kilimann Ingo,
Dyrba Martin,
Brüggen Katharina,
Thyrian Jochen Rene,
Hoffmann Wolfgang
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1545
Subject(s) - dementia , cohort , medicine , diffusion mri , biomarker , fractional anisotropy , population , disease , magnetic resonance imaging , pathology , radiology , biochemistry , chemistry , environmental health
were noted in aMCI group. Conclusions: Resting state FC disturbances were noted in patients with aMCI even before there were detectable structural white matter integrity changes. Functional hyperconnectivity in the sensory-motor and executive control networks might reflect the attempts by the brain to compensate for the functional hypoconnectivity in the DMN aswell as the structural changes in the medial temporal regions. These rsFC aberrations have potential utility as neuroimaging biomarkers of aMCI.