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P3‐167: Predicting and characterizing development of preclinical Alzheimer's disease
Author(s) -
Brier Matthew R.,
McCarthy John E.,
Benzinger Tammie L.S.,
Su Yi,
Friedrichsen Karl A.,
Morris John C.,
Ances Beau,
Vlassenko Andrei
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1538
Subject(s) - pittsburgh compound b , dementia , clinical dementia rating , amyloid (mycology) , correlation , abnormality , nuclear medicine , medicine , alzheimer's disease , neuroimaging , disease , pathology , neuroscience , psychology , mathematics , psychiatry , geometry
and alsowithin ICN-specific cortical regions.Results:We found that even in the absence of any cognitive or structural changes, global cortical Ab burden was associated with functional connectivity in the DMN as well as cortical networks involved in executive control, motor and perceptual timing, and visual detection but not salience processing, attention, and working memory. We also found that there were significant effects of local network Ab burden (i.e., ICN Ab burden) on the network functional connectivity for all ICNs considered in this study; and the effects were associated more closely to local network Ab burden than global Ab burden. Conclusions: The relationship between local network Ab burden and disrupted intrinsic connectivity in various brain networks, in the absence of cognitive deficit and brain atrophy (and presumably absence of cortical tau tangles and neurodegeneration based on previous pathology reports), suggests that neuronal dysfunction may be due to local toxicity of Ab independent of the presence of tau. Furthermore, the results suggest that local toxicity of Ab may represent an early change in preclinical AD.