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P3‐163: Insulin resistance and cerebral amyloid deposition in cognitively healthy and preclinical ad subjects
Author(s) -
Morris Jill K.,
Vidoni Eric D.,
Ward Ashley E.,
Rodriguez Cinthia,
Graves Rasinio S.,
Burns Jeffrey M.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1534
Subject(s) - medicine , insulin resistance , endocrinology , precuneus , impaired fasting glucose , insulin , glucose clamp technique , glucose uptake , amyloid (mycology) , impaired glucose tolerance , pancreatic hormone , pathology , cognition , psychiatry
(VAN), default mode network, and dorsal attention network) was assessed using template based rotation, an approach designed for use with existing network parcellations. A linear regression model with backward elimination (p<0.1 cut-off) was utilized with the FAQ as the dependent variable and the 4 networks as the predictors of interest. Covariates included age, sex, American National Adult Reading Test intelligence quotient (AMNART IQ, a proxy of premorbid IQ), processing speed, episodic memory, and fMRI confounders (signal-to-noise ratio, movement, and bad volumes). Results:There was a significant association between greater IADL impairment and reduced FPCN connectivity (b1⁄4-29.76, partial r(pr)1⁄4-0.36, p1⁄40.03) and increased VAN connectivity (b1⁄437.44, pr1⁄40.40, p1⁄40.02). Covariates retained in the model included premorbid IQ (b1⁄40.26, pr1⁄40.42, p1⁄40.01), processing speed (b1⁄40.12, pr1⁄4-0.37, p1⁄40.03), episodic memory (b1⁄4-0.11, pr1⁄4-0.29, p1⁄40.09), and movement (b1⁄427.61, pr1⁄40.33, p1⁄40.05). The overall model was significant (p1⁄40.005) and accounted for 41% of the variance. There was no significant association with the other networks. Conclusions:These results suggest that IADL impairment inMCI relates to a complex pattern of both reduced and increased connectivity in networks spanning frontal and parietal regions. Similar findings have been reported in a study using a global functioning measure, which consists of both IADL and cognition. Furthermore, reduced FPCNconnectivity has been associatedwith greater apathy, which has been associated with IADL impairment, and increased VAN connectivity has been associated with greater executive dysfunction, which has been associated with IADL impairment.