Premium
IC‐P‐128: Alterations in myelin content are related to cognitive performance in nondemented older adults: Findings from the wisconsin registry for Alzheimer's prevention study
Author(s) -
Sojkova Jitka,
Dean Douglas C.,
Hurley Samuel,
O'Grady Patrick,
Canda Cristybelle,
Davenport Nancy J.,
Asthana Sanjay,
Sager Mark A.,
Johnson Sterling C.,
Gallagher Catherine L.,
Alexander Andrew L.,
Bendlin Barbara B.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.150
Subject(s) - psychology , working memory , cognition , dementia , population , neurocognitive , neuropsychology , effects of sleep deprivation on cognitive performance , medicine , neuroscience , audiology , pathology , disease , environmental health
(AD) and mild cognitive impairment (MCI). Lowered levels of ß-amyloid 1-42 and elevated levels of tau and phopho-tau in cerebro-spinal fluid are related to plaque and tangle formation the neuropathological hallmarks of AD. Little is known about possible interactions of BFCS atrophy and CSF levels of amyloid or tau. Methods:We analyzed high definition 3D structural magnetic resonance imaging data from the European DTI study in dementia (EDSD) of 64 participants with the clinical diagnosis of MCI. All individuals underwent lumbar puncture for CSF analysis. We automatically extracted BFCS volumes from 3DMPRAGE data using a post mortem based mask and determined correlations between volume of the BFCS and CSF levels of amyloid ß 1-42, tau and phospho-tau. Results: CSF levels of total tau were significantly correlated with BFCS volume of Ch4p, Ch4am_al and Ch3 subregions (Mesulam nomenclature), CSF total phospho-tau levels were significantly correlated only with the Ch3 region. Amyloid ß 1-42 levels did not show significant correlation with any of the BFCS subregions. Conclusions:Correlations of CSF tau/phospho-tau and BFCS atrophy agreed with neuropathological findings that neurofibrillary tangles in this area build up early in the course of AD. Furthermore, CSF levels of tau seem to better reflect the degree of atrophy of the BFCS in MCI than CSF amyloid levels.