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IC‐P‐118: Measurement of cortical mean diffusivity detects early microstructural breakdown of the cerebral cortex in presymptomatic familial Alzheimer's disease
Author(s) -
Weston Philip S.J.,
Lehmann Manja,
Simpson Ivor,
Toussaint Nicolas,
Harper Lorna,
Ryan Natalie S.,
MacPherson Kirsty,
Woodward Felix,
Zhang Hui,
Schott Jonathan M.,
Ourselin Sebastien,
Rossor Martin N.,
Nick Fox C.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.140
Subject(s) - precuneus , entorhinal cortex , cortex (anatomy) , white matter , supramarginal gyrus , posterior parietal cortex , neurodegeneration , cerebral cortex , temporal cortex , inferior parietal lobule , neuroscience , medicine , gyrus , pathology , cardiology , psychology , hippocampus , disease , magnetic resonance imaging , radiology , cognition , functional magnetic resonance imaging
N 39 11 11 16 Age, years (SD) 44.7 (9.4) 34.9 (5.3) 42.5 (8.2) 48.6 (9.6) Gender, m/f 16/23 3/8 5/6 11/5 Time to onset, years (SD) 11.7(2.5) 2.9(4.5) Global Clinical dementia 0 0 0 0.88 (0.38) Figure 2. Longitudinal mixed effects modelling, incorporating all scans from all timepoints, showing how A) cortical thickness, and B) rate of change in cortical thickness, both calculated as a mean of all six signature regions, change with time to/from onset (compared to a normal individuals of the same age).